TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of CLK3 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of CLK3 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 5.20E+3nMAssay Description:Inhibition of recombinant CLK3 (unknown origin) using Ac-ERMRPRKRQGSVdP(Sox)G-NH2 as substrate after 5 mins by Omnia Kinase AssayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 2.69E+4nMAssay Description:Inhibition of recombinant CLK3 (unknown origin) using Ac-ERMRPRKRQGSVdP(Sox)G-NH2 as substrate after 5 mins by Omnia Kinase AssayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of CLK3 (unknown origin) by Z'-LYTE assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of CLK3 (unknown origin) by Z'-LYTE kinase assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Ligand Info
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of human CLK3 (275 to 632 residues) expressed in Escherichia coli BL21(DE3) preincubated for 10 mins followed by substrate addition by pyr...More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of human CLK3-4 (275 to 632 residues) expressed in Escherichia coli BL21 (DE3) Turner using S6-peptide as substrate incubated for 60 mins ...More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of human recombinant CLK3 by radiometric assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of recombinant human CLK3 in presence of ATP at Km concentration by radiometric filter-binding assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 87nMAssay Description:Inhibition of recombinant human GST-tagged CLK3 expressed in baculovirus expression system by lantha screen kinase binding assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Ligand Info
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 116nMAssay Description:Inhibition of human full length recombinant CLK3 expressed in baculovirus by measuring substrate phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibition of mouse recombinant CLK3 expressed in Escherichia coli using RS peptide and [gamma-33P]ATP as substrate after 30 minsMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of GST-tagged human recombinant CLK3 expressed in Escherichia coli using RS peptide as substrate incubated for 30 mins in presence of [gam...More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of GST-tagged human recombinant CLK3 expressed in Escherichia coli using RS peptide as substrate incubated for 30 mins in presence of [gam...More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Inhibition of GST-fused mouse recombinant CLK3 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presenc...More data for this Ligand-Target Pair
Affinity DataIC50: 280nMAssay Description:Inhibition of GST tagged recombinant mouse CLK3 expressed in Escherichia coli using RS peptide as substrate after 30 mins by [gamma-33P]ATP based sci...More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Ligand Info
Affinity DataIC50: 310nMAssay Description:Inhibition of GST tagged recombinant mouse CLK3 expressed in Escherichia coli using RS peptide as substrate after 30 mins by [gamma-33P]ATP based sci...More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Inhibition of GST-tagged human recombinant CLK3 expressed in Escherichia coli using RS peptide as substrate incubated for 30 mins in presence of [gam...More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 346nMAssay Description:For kinase inhibition assays, the final concentrations of the enzymes were 15, 14.5, 14.5, and 8.8 nM for CLK1, CLK2, CLK3, and Dyrk1A (Invitrogen, c...More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Ligand Info
Affinity DataIC50: 360nMAssay Description:Inhibition of mouse recombinant GST-tagged CLK3 using GRSRSRSRSRSR as substrateMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 370nMAssay Description:Inhibition of GST tagged recombinant mouse CLK3 expressed in Escherichia coli using RS peptide as substrate after 30 mins by [gamma-33P]ATP based sci...More data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of GST-fused mouse recombinant CLK3 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presenc...More data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:Inhibition of GST-fused mouse recombinant CLK3 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presenc...More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 435nMAssay Description:Inhibition of Clk3 kinase using ATP as substrate by 33P radiolabelled kinase assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of GST-fused mouse recombinant CLK3 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presenc...More data for this Ligand-Target Pair
Affinity DataIC50: 510nMAssay Description:Inhibition of mouse recombinant GST-tagged CLK3 using GRSRSRSRSRSR as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 510nMAssay Description:Inhibition of GST-fused mouse recombinant CLK3 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presenc...More data for this Ligand-Target Pair